Ketamine-Induced Urologic Insult (KIUI)

Ketamine-induced urologic insult (KIUI).

Ketamine-induced cholangiopathy.

Hong Kong Med J ⎥ Volume 20 Number 1 ⎥ February 2014 ⎥ www.hkmj.org A 28-year-old woman presented to us in November 2010 because of deranged liver function test results; predominantly she had raised ductal enzyme levels (gamma-glutamyl transferase, 1088; reference range, 12-57 IU/mL); alkaline phosphatase (ALP) 579 (reference range, 46-127) IU/mL, alanine transaminase (ALT) 183 (reference range...

Scar formation after drug-induced cochlear insult.

Structural and molecular changes in the guinea pig organ of Corti were studied using histochemistry and electron microscopy in the course of drug-induced hair cell degeneration. Actin filaments disappear from the cuticular plate and the stereocilia. An actin-rich bridge appears in the apical region of dying hair cells. Two supporting cells form a scar for a given hair cell. The supporting cells...

Ketamine-induced QTc interval prolongation

Sir, Ketamine is a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor. It is widely used as a dissociative anesthetic and is also used as an adjunct in pain management, particularly in opioid-tolerant patients. It blocks calcium channels and depresses sodium channel function as well as having anticholinergic effects. It inhibits the re-uptake of the catecholamines and may hav...

Ischemic Tolerance Induced by Cerebral Preconditioning: New Urologic Research Area

Voiding function and dysfunction, bladder physiology and pharmacology covering peripheral and central nerve system (CNS) have been given much attention during the last decades as confirmed by countless researches and clinical articles. In contrast, cerebral preconditioning and associated brain lesions in urologic field generated only a few clinical articles regarding to ischemic stroke [1,2]. T...